What Are You Looking For?
Gentiopicroside 98% (CAS 20831-76-9) is a high-purity secoiridoid glycoside isolated from Gentiana lutea (Yellow Gentian). This bioactive compound is extensively studied for its significant anti-inflammatory, hepatoprotective, and gastroprotective properties, making it a critical reference standard for pharmaceutical R&D, nutraceutical formulations, and mechanistic studies.
Product Name :
GentiopicrosideCAS No. :
20831-76-9Appearance :
Off-white crystalline powderSpecification :
80%-98%Source: Centella asiatica Extract
Molecular Formula: C??H??O?
Molecular Weight: 356.33 g/mol
Appearance: Off-white crystalline powder (hygroscopic)
Key Cosmetic Action: Potent Anti-Inflammatory & Skin Barrier Modulator
≥98% Purity (HPLC-validated, λmax 270 nm)
Redness Reducer: Inhibits TNF-α/NF-κB pathway (↓88% IL-6 at 50 μM)
Barrier Repair: Upregulates filaggrin & claudin-1 expression (3.2× vs. control)
Anti-Pigmentation: Suppresses MITF/tyrosinase via IL-1β downregulation
Sensitive Skin Soothing
Rosacea/Redness: 0.5% serum reduces erythema index by 52% in 4 weeks (clinical, *n*=32)
Itch Relief: Blocks histamine H1/H4 receptors (IC??: 18.7 μM)
Anti-Aging & Elasticity
Collagen Defense: Inhibits MMP-1 (81%), MMP-3 (76%), MMP-9 (69%) at 100 μg/mL
Wrinkle Reduction: 1% nanoemulsion ↓ wrinkle depth by 41% in UVB-exposed skin (8-week study)
Hyperpigmentation Control
Melanin Synthesis: Disrupts α-MSH/MC1R signaling (↓43% melanin vs. arbutin)
Post-Inflammatory Marks: 2% cream fades UV-induced spots by 37% in Fitzpatrick IV skin
Parameter | Detail |
---|---|
Purity | ≥98% (HPLC-PDA, Cosmetics Europe compliant) |
Solubility | Water (20 mg/mL), glycerin (80 mg/mL), PG (120 mg/mL) |
pH Stability | 4.0–8.0 (maintains >95% activity) |
Storage | 2–8°C in opaque containers (24-month stability) |
Key Impurities | Loganic acid ≤0.8%, swertiamarin ≤0.5% |
Certifications | ISO 9001, COSMOS Organic, Vegan |
? Serums & Ampoules
Redness Relief: 0.2–0.5% + 1% bisabolol (synergy index 1.6)
Brightening Boost: 1% + 2% niacinamide (↑ glutathione synthesis 2.3×)
? Creams & Emulsions
Barrier Creams: 0.5–1% in ceramide systems (↑59% TEWL recovery)
Anti-Aging: 1% + 0.3% retinol (↓78% irritation)
? Suncare & After-Sun
UV Repair: 0.3% in aloe vera gel (↓65% sunburn cells)
Anti-Pollution: 0.2% + ectoin (↑2.1× Nrf2 activation)
Green Extraction: Ultrasonic-assisted + D101 resin purification (93.5% yield, solvent-free)
Bioavailability: β-cyclodextrin inclusion complexes (↑3.8× skin penetration vs. free form)
Stability: Photostable with 0.05% tocopheryl acetate + 1% octinoxate (96% retention after 3J/cm² UVA)
Quantity | Format | Shelf Life |
---|---|---|
100 g | Pharma HDPE jar + nitrogen | 24 months |
500 g | Vacuum-sealed aluminum bag | 24 months |
1 kg | UV-block PET drum (2–8°C, RH<30%) | 24 months |
Dermal Safety: Non-irritating (HET-CAM test), non-comedogenic (comedogenicity index: 0.1)
Allergen-Free: Gluten-free, non-GMO, no synthetic preservatives
Heavy Metals: As <0.1 ppm, Pb <0.2 ppm (ISO 21392 compliant)
Q: How to incorporate into water-based serums?
*A: Pre-dissolve in glycerin (1:4 ratio) → add to aqueous phase at <40°C.*
Q: Efficacy in acidic formulations (AHA/BHA)?
A: Stable at pH 3.5–5.5; enhances AHA efficacy (↑33% collagen I vs. AHA alone).
Q: Synergy with brightening actives?
*A: Combine with tranexamic acid (↓58% melanin) or α-arbutin (↑1.9× tyrosinase inhibition).*